Inoculation of Growth Control Tube/Drug Containing Tubes
It is extremely important to perform quality control of drug susceptibility testing periodically.
Inoculum Preparation from MGIT Positive Culture
Inoculation Preparation for Drug-containing Tube (1-2 days)
Inoculum Preparation for First and Second-line Phenotypic DST
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Label the required number of 7 mL MGIT tubes with lab ID. In addition, label tubes with one of each of the following: GC (Growth Control), drug 1, drug 2 etc.
Preparation and Storage of Second-line Anti-TB Drugs used for DST
Preparation and Storage of Second-line Anti-TB Drugs used for DST
Critical Concentration and formulations of Second-line Anti-TB Drugs for DST
Preparation of second-line drug stock:
Second-line Phenotypic Drug Susceptibility Testing
Multidrug-resistant (MDR) TB is caused by strains of MTB resistant to at least isoniazid and rifampicin; for effective MDR patient management, optimized treatment regimens are required.
Critical Concentration and Reconstitution of PZA
Critical Concentration for PZA Drugs Recommended for the Treatment of DS- TB
Pyrazinamide PZA Susceptibility Testing
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The BACTEC MGIT 960 PZA medium tube contains 7 ml of broth.
Critical Concentrations and Reconstitution of SIRE Drugs
BACTEC MGIT 960 SIRE Kit for critical concentrations contains the following drugs in lyophilized form.
SIRE Susceptibility Testing
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The BACTEC MGIT 960 susceptibility testing for Streptomycin (S), Isoniazid (I), Rifampin (R) and Ethambutol (E), called SIRE, is a rapid and qualitative method that uses critical test concentrations of the four drugs.