Possible Adverse Events Due to Drugs in Shorter Oral Bedaquiline-containing MDR/RR-TB Regimen

Drugs that are part of the shorter Bedaquiline (Bdq)-containing regimen have some typical side effects which need close monitoring of Drug Resistant-TB (DR-TB) patients while providing the treatment.

 

Table: Possible adverse events due to drugs in the shorter oral Bedaquiline-containing MDR/RR-TB regimen; Source: Guidelines for PMDT in India, 2021.

Shorter Oral Bedaquiline-containing MDR/RR-TB Regimen: Dosage of Drugs for Adults

In adults, the dosage of drugs for a shorter oral Bedaquiline (Bdq) - containing Multi-drug Resistant (MDR)/ Rifampicin-resistant Tuberculosis (RR-TB) regimen, varies according to their weight. 

 

The table below provides drug dosages for adult patients, according to their weight bands, in a shorter oral Bedaquiline-containing MDR/RR-TB regimen.

 

Table: Weight-bandwise Dosages for Adult Patients on Shorter Oral Bdq-containing MDR/ RR-TB Regimen

Sr No

Drugs

Sequence of Using Replacement Drugs to Modify the Longer Oral M/XDR-TB Regimen​

Table 1 shows the sequence of using replacement drugs to modify the longer oral multi (M)/extensively drug-resistant TB (XDR-TB) regimen. The physician at the nodal and district DR-TB centres (N/DDR-TBC) should use this table to replace the drugs to modify the regimen.

 

Sr. No

Drugs to be replaced

Number of drugs to include from

Final regimen after replacement

Group A 

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