List of Drugs that can be Used Safely or Avoided along with Bedaquiline

List of Drugs that can be Used Safely or Avoided along with Bedaquiline

Learning Objectives

List of Drugs that can be Used Safely or Avoided along with Bedaquiline

Content

Certain drugs can be used safely while others need to be avoided along with Bedaquiline (Bdq).

The table below provides the list of drugs that should be avoided when Bdq is part of the regimen as well as the drugs that are safe to use with Bdq.

Table: Safe and Contraindicated Drugs with Bedaquiline during Treatment; *Source: Guidelines for PMDT, India 2021, p52.*
GROUP	SAFE TO USE	DRUGS TO BE AVOIDED
Antiemetics	Metoclopramide	Domperidone, Ondansetron
Analgesics	NSAIDs, Paracetamol	Tramadol
Antacids	Ranitidine, Milk of Magnesia	Pantoprazole, Omeprazole
Antihistaminics	Pheniramine, Fexofenadine, Cetirizine	Diphenhydramine, Loratadine
Antimalarials	Artesunate	Chloroquine
Antibiotics	Penicillins, Cephalosporins, Tinidazole	Ciprofloxacin, Norfloxacin, Cotrimoxazole, Metronidazole
Antifungals	Terbinafine	Fluconazole, Ketoconazole, Itraconazole
Antiepileptics	Sodium Valproate	Phenytoin, Carbamazepine, Phenobarbital
Antidiabetics	Mostly safe	-
Antihypertensives	Safe (except Diuretics)	Diuretics
Lipid-lowering Agents	-	Statins are best to be avoided
Antiarrhythmics	Diltiazem, Lignocaine	Amiodarone, Procainamide, Digoxin
Other Cardiac Drugs	Nitroglycerine, Sorbitrate	Sotalol
Antiretrovirals	Tenofovir, Zidovudine, Nevirapine, Dolutegravir	Efavirenz, Lopinavir, Ritonavir
Anxiolytics	Benzodiazepines (Alprazolam)	Avoid other sedatives
Antipsychotics	Risperidone, Lurasidone	Haloperidol, Clozapine, Quetiapine, Olanzapine
Antidepressants	Best to be avoided, only give if essential with ECG monitoring	Citalopram, Fluoxetine, Sertraline

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