A0

Adverse Drug Reactions (ADRs), such as renal toxicity, may occur from the Drug-resistant TB (DR-TB) treatment regimen.

Suspected agent(s): Amikacin (Am)

Adverse Drug Reactions (ADRs), such as seizures, may occur from the Drug-resistant TB (DR-TB) treatment regimen.

Suspected agent(s): Cycloserine (Cs), Isoniazid (H), Fluoroquinolone (FQ)

Suggested Management Strategies

Adverse Drug Reaction (ADR), such as suicidal ideation, may occur from the Drug-resistant TB (DR-TB) treatment regimen.

​​Suspected agent(s): Cycloserine (Cs), Isoniazid (H), Ethionamide (Eto)

Suggested Management Strategies

• Hospitalize the patient and put them under 24-hour surveillance.
• Discontinue Cs.
• Request psychiatric consultation. 
• Initiate antidepressant treatment.
• Lower the dose of Eto until the patient is stable.

Adverse Drug Reactions (ADRs), such as psychotic symptoms, may occur from the Drug-resistant TB (DR-TB) treatment regimen.

Suspected agent(s): Cycloserine (Cs), Isoniazid (H), Fluoroquinolone (FQ)

Suggested Management Strategies

Adverse Drug Reaction (ADR), such as depression, may occur from the Drug-resistant TB (DR-TB) treatment regimen.

Suspected agent(s): Cycloserine (Cs), Fluoroquinolone (FQ), Isoniazid (H), Ethionamide (Eto)

Psychological and socioeconomic circumstances, chronic disease are also important factors of depression.

Suggested Management Strategies

Adverse Drug Reactions (ADRs), such as arthralgia, may occur from the Drug-resistant TB (DR-TB) treatment regimen.

Suspected agent(s): Pyrazinamide (Z), Fluoroquinolone (FQ), Bedaquiline (Bdq)

Suggested Management Strategies​

Adverse Drug Reactions (ADRs), such as hypothyroidism, may occur from the Drug-resistant TB (DR-TB) treatment regimen.

Figure: Symptoms of Hypothyroidism

Suspected agent(s): Ethionamide (Eto), Para Aminosalicylic Acid (PAS)   Suggested Management Strategies:

Adverse Drug Reactions (ADRs), such as haematological abnormalities, may occur from the Drug-resistant TB (DR-TB) treatment regimen.

Suspected agent(s): Linezolid (Lzd)

Suggested Management Strategies

Adverse Drug Reaction (ADR), such as giddiness, may occur from the Drug-resistant TB (DR-TB) treatment regimen.

Suspected agent(s) - Amikacin (Am), Ethionamide (Eto), Fluoroquinolone (FQ) and/or Pyrazinamide (Z)

Suggested Management Strategies

Adverse Drug Reactions (ADRs), such as diarrhoea and/or flatulence, may occur from the Drug-resistant TB (DR-TB) treatment regimen.

Suspected agent(s): Para Aminosalicylic Acid (PAS), Ethionamide (Eto)

Suggested Management Strategies