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Trueprep Error Classes

The Trueprep errors are classified as:

Monitoring of Truenat errors

There are various types of errors that occur with the Truenat machines, which include:

• Coded errors related to the Trueprep AUTO v2 sample prep device
• Coded errors related to the Truelab micro-PCR Analyzer
• Non-coded system errors/failures

Monitoring the Trueprep AUTO v2 errors  

After completion of the set number of nucleic acid extractions (i.e., buffer count 05/ 25/ 50/ 100 completed) the Trueprep AUTO v2 device will prompt the alert on its 2- line LCD screen to “Change the reagent pack” and “Insert Reagent Reset Card & Start” on the screen alternatively. When this happens, the new reagent pack needs to be inserted into the device and the buffer count needs to be reset.

Evaluation of stores and stocks under the National TB Elimination Programme (NTEP) is important to ensure an uninterrupted supply of anti-TB drugs to patients and avoid the expiry of drugs.

The evaluation also looks at the optimal performance of the supply chain management and informs the policy if there is any need to address certain critical checkpoints for optimal performance at all levels.

This is facilitated through the Ni-kshay Aushadhi application and the physical stock registers.

Drugs that are part of the shorter Bedaquiline (Bdq)-containing regimen have some typical side effects which need close monitoring of Drug Resistant-TB (DR-TB) patients while providing the treatment.

In adults, the dosage of drugs for a shorter oral Bedaquiline (Bdq) - containing Multi-drug Resistant (MDR)/ Rifampicin-resistant Tuberculosis (RR-TB) regimen, varies according to their weight. 

The table below provides drug dosages for adult patients, according to their weight bands, in a shorter oral Bedaquiline-containing MDR/RR-TB regimen.

Table 1 shows the sequence of using replacement drugs to modify the longer oral multi (M)/extensively drug-resistant TB (XDR-TB) regimen. The physician at the nodal and district DR-TB centres (N/DDR-TBC) should use this table to replace the drugs to modify the regimen.

It is important to know the dosages of Multi (M)/ Extensively Drug-resistant TB (XDR-TB) drugs for adults on a longer oral M/XDR-TB regimen.​

The table below shows the M/XDR-TB regimen drugs for adults weight band-wise, used in longer oral M/XDR-TB regimen customized for India by national experts.

When there is a modification in the Drug-resistant TB (DR-TB) regimen as suggested by the Drug-Resistant Tuberculosis Centre (DR-TBC), the district drug storekeeper/ pharmacist prepares the modified boxes from loose Second-line anti-TB Drugs (SLD) supplied from the State Drug Store (SDS). 

The principles of designing Drug-resistant TB (DR-TB) treatment regimens (Shorter or longer oral Multi (M)/ Extensively Drug-resistant TB (XDR-TB), and H mono/ poly DR-TB regimens in children are similar to adults: