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Screening among Household Contacts of DR-TB Patients

The National TB Elimination Programme (NTEP) follows an integrated algorithm for screening and ruling out active Tuberculosis (TB) among Household Contacts (HHCs) of Drug-resistant Tuberculosis (DR-TB) patients.

 

Figure: Integrated Algorithm for Screening and Ruling out Active TB among HHCs of DR-TB Patients; Source: Guidelines for PMDT in India, 2021, p118.

 

Treatment Regimen for Non-Mycobacterium Tuberculosis [NTM]

The suggested treatment regimen covering maximum non-Mycobacterium Tuberculosis (NTM) mainly Mycobacterium Avium Complex (MAC) is as follows: 

  • Rifampicin (R) 450-600 mg OD
  • Ethambutol (E) 800-1200 mg OD
  • Clarithromycin (Clr) 1 gm OD (split into two doses)
  • Add injection Amikacin (Am) 750 mg – 1 gm thrice weekly for the first 2-3 months

 

Intensive Phase (IP) is for 3 months and can be extended to a maximum of 6 months with all four drugs. 

 

Supportive Measures in Palliative Care

It is very important that medical care continues and the patient is not abandoned once the therapy has been suspended. Several supportive measures can be used for this.

Dyspnoea, and to a much lesser extent pain, are among the most distressing symptoms in the last stages of the disease. Thus, access to opioids and other controlled medicines is fundamental for delivering high standards of palliative and end-of-life care to patients with Multidrug-resistant Tuberculosis (MDR-TB).

 

The details on palliative care supportive measures are as below:

Patient Turnaround Time from Identification to Treatment Initiation Relative to the Laboratory Technology Used in DR-TB

The concept of Patient Turnaround Time (P-TAT) is to find out how much time was taken from the identification of the patient for a test to getting the result of that test and initiation of patient's treatment based on the test result.

 

The National TB Elimination Programme (NTEP) have set benchmarks to monitor the P-TAT as provided in the table below. 

 

Final Treatment Outcomes of DR-TB Cases

Under the National TB Elimination Programme (NTEP), the treatment outcome definitions of Drug-susceptible TB (DS-TB) and Drug-resistant TB (DR-TB) have been aligned in recent times. However, the treatment outcome is declared at different time points for certain outcomes (e.g., cured/ treatment completed) since the duration of DR-TB treatment is longer when compared to DS-TB treatment

 

Table: Final DR-TB Treatment Outcomes

TREATMENT OUTCOMES

DEFINITION

Palliative Care in DR-TB

The World Health Organization (WHO) defines palliative care as an approach that improves the quality of life of patients and their families facing the problems associated with life-threatening illnesses, through prevention and relief of suffering by means of early identification, impeccable assessment, and treatment of pain and other physical, psychosocial and spiritual problems.

 

The goal of such treatment is to improve the quality of life for both the patient and their family. 

 

Inventory Management of CBNAAT Cartridges and Truenat Chips

The inventory of Cartridge Based Nucleic Acid Amplification Test (CBNAAT) cartridges and Truenat chips supplied by the centre or procured by the states/ districts should be managed through Nikshay Aushadhi (see the figure below).

Figure: Inventory Management of NAAT Cartridges/ Chips in Nikshay Aushadhi Portal; Source: Guidelines for PMDT, India, 2021, p142.

 

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